Transdermal estrogen, which is absorbed directly through the skin, offers one option for relief of menopausal symptoms. These FDA (Food and Drug Administration)-approved products include gels, an emulsion, and a spray. The gels (Divigel, Elestrin, Estrogel) and emulsion lotion (Estrasorb) are applied to the arms or legs as directed. The spray (Evamist) is applied to the inside of the forearm between the elbow and the wrist. There are also estrogen creams prepared and dispensed from compounding pharmacies but these are not approved by the FDA.
A number of reports have been filed with the FDA describing the unintended transfer of estrogen to children and pets from the skin of women using Evamist. Reports in the medical and veterinary literature also describe unintended transfer of compounded estrogen creams to children and pets.
Children show signs of premature puberty:
Pets show signs of excess estrogen:
*It probably makes sense for women using other topical estrogens, especially compounded estrogen creams, to consider similar precautions. More information is available at the FDA website.
This information from The North American Menopause Society (NAMS) is not to be used as a medical diagnosis. This page may be photocopied. For all questions about medical issues, NAMS recommends that patients consult their healthcare providers.
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